NFL Leaders |
Carries
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1 | L. Fournette | Jax | 7 | 144 | 715 | 102.1 | 4.97 | 1 |
| 2 | C. Carson | Sea | 7 | 139 | 569 | 81.3 | 4.09 | 2 |
| 3t | E. Elliott | Dal | 7 | 135 | 602 | 86.0 | 4.46 | 6 |
| 3t | D. Henry | Ten | 7 | 135 | 506 | 72.3 | 3.75 | 5 |
| 5 | D. Cook | Min | 7 | 133 | 725 | 103.6 | 5.45 | 8 |
| 6 | C. McCaffrey | Car | 6 | 127 | 618 | 103.0 | 4.87 | 7 |
| 7t | M. Mack | Ind | 6 | 119 | 514 | 85.7 | 4.32 | 2 |
| 7t | S. Michel | NE | 7 | 119 | 390 | 55.7 | 3.28 | 6 |
| 9 | N. Chubb | Cle | 6 | 114 | 607 | 101.2 | 5.32 | 6 |
| 10 | C. Hyde | Hou | 7 | 111 | 461 | 65.9 | 4.15 | 3 |
| 11 | J. Jacobs | Oak | 6 | 109 | 554 | 92.3 | 5.08 | 4 |
| 12 | A. Jones | GB | 7 | 101 | 399 | 57.0 | 3.95 | 8 |
| 13 | L. Bell | NYJ | 6 | 100 | 326 | 54.3 | 3.26 | 1 |
| 14 | M. Ingram II | Bal | 7 | 99 | 470 | 67.1 | 4.75 | 7 |
| 15 | P. Lindsay | Den | 7 | 95 | 433 | 61.9 | 4.56 | 4 |
| 16 | K. Johnson | Det | 6 | 92 | 308 | 51.3 | 3.35 | 2 |
| 17t | F. Gore | Buf | 6 | 86 | 388 | 64.7 | 4.51 | 2 |
| 17t | A. Kamara | NO | 6 | 86 | 373 | 62.2 | 4.34 | 1 |
| 19t | D. Freeman | Atl | 7 | 84 | 294 | 42.0 | 3.50 | 0 |
| 19t | J. Mixon | Cin | 7 | 84 | 254 | 36.3 | 3.02 | 0 |
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