NFL Leaders |
Rushing Touchdowns
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1t | D. Henry | Ten | 15 | 303 | 1540 | 102.7 | 5.08 | 16 |
| 1t | A. Jones | GB | 16 | 236 | 1084 | 67.8 | 4.59 | 16 |
| 3 | C. McCaffrey | Car | 16 | 287 | 1387 | 86.7 | 4.83 | 15 |
| 4 | D. Cook | Min | 14 | 250 | 1135 | 81.1 | 4.54 | 13 |
| 5t | E. Elliott | Dal | 16 | 301 | 1357 | 84.8 | 4.51 | 12 |
| 5t | T. Gurley II | LAR | 15 | 223 | 857 | 57.1 | 3.84 | 12 |
| 7 | M. Ingram II | Bal | 15 | 202 | 1018 | 67.9 | 5.04 | 10 |
| 8 | J. Allen | Buf | 16 | 109 | 510 | 31.9 | 4.68 | 9 |
| 9t | N. Chubb | Cle | 16 | 298 | 1494 | 93.4 | 5.01 | 8 |
| 9t | K. Drake | Ari | 14 | 170 | 817 | 58.4 | 4.81 | 8 |
| 9t | M. Gordon III | LAC | 12 | 162 | 612 | 51.0 | 3.78 | 8 |
| 9t | M. Mack | Ind | 14 | 247 | 1091 | 77.9 | 4.42 | 8 |
| 9t | R. Mostert | SF | 16 | 137 | 772 | 48.3 | 5.64 | 8 |
| 14t | C. Carson | Sea | 15 | 278 | 1230 | 82.0 | 4.42 | 7 |
| 14t | L. Jackson | Bal | 15 | 176 | 1206 | 80.4 | 6.85 | 7 |
| 14t | J. Jacobs | Oak | 13 | 242 | 1150 | 88.5 | 4.75 | 7 |
| 14t | P. Lindsay | Den | 16 | 224 | 1011 | 63.2 | 4.51 | 7 |
| 14t | S. Michel | NE | 16 | 247 | 912 | 57.0 | 3.69 | 7 |
| 14t | D. Watson | Hou | 15 | 82 | 413 | 27.5 | 5.04 | 7 |
| 20t | P. Barber | TB | 16 | 154 | 470 | 29.4 | 3.05 | 6 |
| 20t | S. Barkley | NYG | 13 | 217 | 1003 | 77.2 | 4.62 | 6 |
| 20t | T. Coleman | SF | 14 | 137 | 544 | 38.9 | 3.97 | 6 |
| 20t | J. Howard | Phi | 10 | 119 | 525 | 52.5 | 4.41 | 6 |
| 20t | C. Hyde | Hou | 16 | 245 | 1070 | 66.9 | 4.37 | 6 |
| 20t | R. Jones II | TB | 16 | 172 | 724 | 45.3 | 4.21 | 6 |
| 20t | D. Montgomery | Chi | 16 | 242 | 889 | 55.6 | 3.67 | 6 |
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