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| Toray Pan Pacific Open | ||
| Surface: Hard | Date: Sep. 17 - Sep. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Gavrilova | Win | 4-6, 6-4, 6-4 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Zarina Diyas | Win | 6-4, 7-6 (7-4) |
| Second Round | Ana Bogdan | Win | 6-2, 6-3 |
| Third Round | Sofia Kenin | Win | 6-4, 7-6 (7-2) |
| Fourth Round | Ashleigh Barty | Win | 6-4, 6-4 |
| Quarterfinals | Serena Williams | Loss | 4-6, 3-6 |
| Connecticut Open presented by United Technologies | ||
| Surface: Hard | Date: Aug. 19 - Aug. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterina Makarova | Loss | 1-6, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Agnieszka Radwanska | Win | 6-3, 6-3 |
| Second Round | Aryna Sabalenka | Loss | 6-2, 3-6, 5-7 |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | 6-4, 6-4 |
| Second Round | Kiki Bertens | Loss | 2-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Harriet Dart | Win | 7-6 (7-2), 2-6, 6-1 |
| Second Round | Victoria Azarenka | Win | 6-3, 6-3 |
| Third Round | Mihaela Buzarnescu | Win | 3-6, 7-6 (7-3), 6-1 |
| Fourth Round | Kiki Bertens | Loss | 3-6, 6-7 (1-7) |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 24 - Jun. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Win | 6-4, 2-6, 6-3 |
| Third Round | Barbora Strycova | Win | 6-3, 6-4 |
| Quarterfinals | Aryna Sabalenka | Loss | 3-6, 6-2, 6-7 (5-7) |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Magdalena Rybarikova | Loss | 2-6, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Barbora Krejcikova | Win | 7-6 (8-6), 6-4 |
| Second Round | Lucie Safarova | Win | 3-6, 6-4, 6-1 |
| Third Round | Maria Sharapova | Loss | 2-6, 1-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Maria Sakkari | Loss | 6-3, 3-6, 5-7 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Elena Vesnina | Win | 6-4, 6-2 |
| Second Round | Victoria Azarenka | Win | 6-2, 1-6, 7-5 |
| Third Round | Sloane Stephens | Win | 6-2, 6-3 |
| Quarterfinals | Simona Halep | Win | 6-4, 6-3 |
| Semifinals | Petra Kvitova | Loss | 6-7 (4-7), 3-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Kiki Bertens | Win | 6-2, 6-2 |
| Second Round | Veronika Kudermetova | Win | 7-6 (7-4), 6-3 |
| Quarterfinals | Jelena Ostapenko | Win | 5-7, 7-5, 6-4 |
| Semifinals | Anett Kontaveit | Win | 6-4, 6-2 |
| Final | Coco Vandeweghe | Win | 7-6 (7-2), 6-4 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ekaterina Makarova | Win | 7-5, 7-5 |
| Third Round | Su-Wei Hsieh | Win | 6-4, 1-6, 7-6 (7-4) |
| Fourth Round | Zarina Diyas | Win | 6-2, 2-1 Retired |
| Quarterfinals | Victoria Azarenka | Loss | 5-7, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Irina-Camelia Begu | Win | 7-6 (7-4), 6-1 |
| Third Round | Shuai Zhang | Win | 7-5, 5-7, 6-3 |
| Fourth Round | Amanda Anisimova | Win | 6-1, 7-6 (7-2) |
| Quarterfinals | Naomi Osaka | Loss | 2-6, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Carla Suarez Navarro | Win | 5-7, 6-2, 6-4 |
| Quarterfinals | Angelique Kerber | Loss | 4-6, 3-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Win | 6-2, 6-3 |
| Third Round | Catherine Bellis | Loss | 6-7 (4-7), 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Veronica Cepede Royg | Win | 6-3, 6-4 |
| Second Round | Beatriz Haddad Maia | Win | 6-1, 6-1 |
| Third Round | Lucie Safarova | Win | 7-6 (8-6), 7-5 |
| Fourth Round | Barbora Strycova | Win | 6-7 (5-7), 6-3, 6-2 |
| Quarterfinals | Simona Halep | Loss | 3-6, 2-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Catherine Bellis | Win | 6-1, 6-1 |
| Quarterfinals | Kaia Kanepi | Win | 3-6, 7-5, 6-2 |
| Semifinals | Elina Svitolina | Loss | 5-7, 5-7 |
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