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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jelena Ostapenko | Loss | 5-7, 6-3, 5-7 |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 22 - Sep. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Amanda Anisimova | Win | 6-3, 6-3 |
| Third Round | Dayana Yastremska | Loss | 1-6, 4-6 |
| Zhengzhou Open | ||
| Surface: Hard | Date: Sep. 9 - Sep. 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Polona Hercog | Win | 6-3, 7-5 |
| Quarterfinals | Sofia Kenin | Win | 6-4, 4-6, 6-1 |
| Semifinals | Ajla Tomljanovic | Win | 6-3, 6-2 |
| Final | Petra Martic | Win | 6-3, 6-2 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Tereza Martincova | Win | 7-6 (8-6), 7-6 (7-3) |
| Second Round | Mariam Bolkvadze | Win | 6-1, 6-4 |
| Third Round | Ons Jabeur | Win | 6-1, 4-6, 6-4 |
| Fourth Round | Johanna Konta | Loss | 7-6 (7-1), 3-6, 5-7 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yafan Wang | Win | 6-1, 6-3 |
| Third Round | Rebecca Peterson | Win | 7-5, 6-4 |
| Quarterfinals | Svetlana Kuznetsova | Loss | 6-3, 6-7 (2-7), 3-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Riske | Win | 6-4, 6-7 (4-7), 6-2 |
| Third Round | Anett Kontaveit | Win | 6-3, 7-5 |
| Quarterfinals | Bianca Andreescu | Loss | 0-6, 6-2, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Lin Zhu | Win | 6-2, 7-6 (7-4) |
| Second Round | Monica Puig | Win | 6-0, 6-4 |
| Third Round | Su-Wei Hsieh | Win | 6-3, 2-6, 6-4 |
| Fourth Round | Karolina Muchova | Loss | 6-4, 5-7, 11-13 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Margarita Gasparyan | Win | 6-3, 6-3 |
| Third Round | Elise Mertens | Win | 6-1, 6-2 |
| Quarterfinals | Ekaterina Alexandrova | Win | 6-2, 6-0 |
| Semifinals | Kiki Bertens | Win | 6-1, 6-2 |
| Final | Angelique Kerber | Win | 6-1, 6-4 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Mihaela Buzarnescu | Win | 6-3, 6-4 |
| Second Round | Kristyna Pliskova | Loss | 2-6, 6-3, 6-7 (7-9) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Madison Brengle | Win | 6-2, 6-3 |
| Second Round | Kristina Kucova | Win | 6-2, 6-2 |
| Third Round | Petra Martic | Loss | 3-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Win | 6-3, 6-3 |
| Third Round | Sofia Kenin | Win | 4-6, 6-4, 6-3 |
| Quarterfinals | Victoria Azarenka | Win | 6-7 (5-7), 6-2, 6-2 |
| Semifinals | Maria Sakkari | Win | 6-4, 6-4 |
| Final | Johanna Konta | Win | 6-3, 6-4 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Dayana Yastremska | Win | 5-7, 7-6 (7-5), 6-3 |
| Second Round | Kateryna Kozlova | Loss | 5-7, 6-2, 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Victoria Azarenka | Loss | 6-4, 3-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Martic | Win | 6-3, 6-4 |
| Third Round | Alize Cornet | Win | 6-7 (3-7), 6-1, 6-4 |
| Fourth Round | Yulia Putintseva | Win | 2-6, 6-3, 7-5 |
| Quarterfinals | Marketa Vondrousova | Win | 6-3, 6-4 |
| Semifinals | Simona Halep | Win | 7-5, 6-1 |
| Final | Ashleigh Barty | Loss | 6-7 (1-7), 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Misaki Doi | Win | 6-7 (4-7), 6-1, 6-1 |
| Third Round | Ysaline Bonaventure | Win | 6-3, 6-2 |
| Fourth Round | Anett Kontaveit | Win | 7-6 (7-0), 4-6, 6-2 |
| Quarterfinals | Belinda Bencic | Loss | 3-6, 6-4, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominika Cibulkova | Win | 6-2, 3-6, 6-3 |
| Third Round | Alison Riske | Win | 7-6 (7-3), 7-6 (7-5) |
| Quarterfinals | Su-Wei Hsieh | Loss | 4-6, 6-1, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Karolina Muchova | Win | 6-3, 6-2 |
| Second Round | Madison Brengle | Win | 4-6, 6-1, 6-0 |
| Third Round | Camila Giorgi | Win | 6-4, 3-6, 6-2 |
| Fourth Round | Garbine Muguruza | Win | 6-3, 6-1 |
| Quarterfinals | Serena Williams | Win | 6-4, 4-6, 7-5 |
| Semifinals | Naomi Osaka | Loss | 2-6, 6-4, 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 6 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Win | 4-6, 6-3, 6-4 |
| Second Round | Marie Bouzkova | Win | 7-5, 6-2 |
| Quarterfinals | Ajla Tomljanovic | Win | 6-1, 1-6, 6-1 |
| Semifinals | Donna Vekic | Win | 6-3, 6-4 |
| Final | Lesia Tsurenko | Win | 4-6, 7-5, 6-2 |
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