| ||||||||||||||
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Natalia Vikhlyantseva | Win | 6-2, 6-3 |
| Third Round | Camila Giorgi | Win | 6-3, 4-6, 6-0 |
| Quarterfinals | Caroline Wozniacki | Win | 6-2, 6-4 |
| Semifinals | Garbine Muguruza | Loss | 3-6, 2-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Win | 6-3, 6-3 |
| Third Round | Naomi Osaka | Win | 6-2, 6-7 (4-7), 1-0 Retired |
| Quarterfinals | Caroline Wozniacki | Loss | 5-7, 7-6 (7-3), 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Evgeniya Rodina | Win | 6-1, 6-4 |
| Second Round | Magdalena Rybarikova | Loss | 6-3, 5-7, 2-6 |
| AEGON International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Riske | Win | 6-4, 6-3 |
| Third Round | Shuai Peng | Win | 7-6 (7-3), 6-4 |
| Quarterfinals | Svetlana Kuznetsova | Win | 6-7 (7-9), 6-2, 6-4 |
| Semifinals | Johanna Konta | Win | Retired |
| Final | Caroline Wozniacki | Win | 6-4, 6-4 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 7-5, 6-2 |
| Second Round | Ekaterina Alexandrova | Win | 6-2, 4-6, 6-3 |
| Third Round | Carina Witthoeft | Win | 7-5, 6-1 |
| Fourth Round | Veronica Cepede Royg | Win | 2-6, 6-3, 6-4 |
| Quarterfinals | Caroline Garcia | Win | 7-6 (7-3), 6-4 |
| Semifinals | Simona Halep | Loss | 4-6, 6-3, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lauren Davis | Win | 6-1, 6-1 |
| Third Round | Timea Bacsinszky | Win | 6-1, 7-5 |
| Quarterfinals | Elina Svitolina | Loss | 2-6, 6-7 (9-11) |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Lesia Tsurenko | Win | 7-6 (7-5), 2-6, 6-2 |
| Second Round | Anastasija Sevastova | Loss | 3-6, 3-6 |
| J&T Banka Prague Open | ||
| Surface: Clay | Date: May 1 - May 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Camila Giorgi | Loss | 6-7 (6-8), 2-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Coco Vandeweghe | Win | 7-6 (7-2), 6-4 |
| Quarterfinals | Laura Siegemund | Loss | 6-7 (3-7), 7-5, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Madison Brengle | Win | 6-1, 6-3 |
| Third Round | Yulia Putintseva | Win | 7-5, 6-3 |
| Fourth Round | Barbora Strycova | Win | 6-1, 6-4 |
| Quarterfinals | Mirjana Lucic-Baroni | Win | 6-3, 6-4 |
| Semifinals | Caroline Wozniacki | Loss | 7-5, 1-6, 1-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Monica Puig | Win | 1-6, 6-4, 6-4 |
| Third Round | Irina-Camelia Begu | Win | 6-4, 7-6 (7-2) |
| Fourth Round | Timea Bacsinszky | Win | 5-1 Retired |
| Quarterfinals | Garbine Muguruza | Win | 7-6 (7-2), 7-6 (7-5) |
| Semifinals | Svetlana Kuznetsova | Loss | 6-7 (5-7), 6-7 (2-7) |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Mladenovic | Loss | 2-6, 4-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Garcia | Win | 7-5, 6-4 |
| Quarterfinals | Shuai Zhang | Win | 6-2, 6-0 |
| Semifinals | Dominika Cibulkova | Win | 6-4, 4-6, 6-3 |
| Final | Caroline Wozniacki | Win | 6-3, 6-4 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Sara Sorribes Tormo | Win | 6-2, 6-0 |
| Second Round | Anna Blinkova | Win | 6-0, 6-2 |
| Third Round | Jelena Ostapenko | Win | 4-6, 6-0, 10-8 |
| Fourth Round | Daria Gavrilova | Win | 6-3, 6-3 |
| Quarterfinals | Mirjana Lucic-Baroni | Loss | 4-6, 6-3, 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Win | 6-3, 6-1 |
| Second Round | Asia Muhammad | Win | 6-1, 6-4 |
| Quarterfinals | Roberta Vinci | Win | 3-6, 6-2, 6-2 |
| Semifinals | Elina Svitolina | Win | 6-2, 6-4 |
| Final | Alize Cornet | Win | 6-0, 6-3 |
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