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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Aliaksandra Sasnovich | Win | 6-2, 2-6, 6-1 |
| Second Round | Elise Mertens | Win | 6-3, 7-6 (7-5) |
| Third Round | Jennifer Brady | Win | 6-1, 6-3 |
| Quarterfinals | Naomi Osaka | Loss | 7-5, 3-6, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Katie Volynets | Win | 6-2, 6-4 |
| Second Round | Kirsten Flipkens | Win | 6-3, 7-5 |
| Third Round | Caroline Wozniacki | Win | 6-4, 6-4 |
| Fourth Round | Taylor Townsend | Win | 6-1, 4-6, 6-2 |
| Quarterfinals | Elise Mertens | Win | 3-6, 6-2, 6-3 |
| Semifinals | Belinda Bencic | Win | 7-6 (7-3), 7-5 |
| Final | Serena Williams | Win | 6-3, 7-5 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Eugenie Bouchard | Win | 4-6, 6-1, 6-4 |
| Second Round | Daria Kasatkina | Win | 5-7, 6-2, 7-5 |
| Third Round | Kiki Bertens | Win | 6-1, 6-7 (7-9), 6-4 |
| Quarterfinals | Karolina Pliskova | Win | 6-0, 2-6, 6-4 |
| Semifinals | Sofia Kenin | Win | 6-4, 7-6 (7-5) |
| Final | Serena Williams | Win | 3-1 Retired |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Marie Bouzkova | Win | 5-7, 6-4, 6-4 |
| Second Round | Sofia Kenin | Loss | Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Irina-Camelia Begu | Win | 4-6, 7-6 (7-2), 6-2 |
| Second Round | Sofia Kenin | Win | 6-3, 6-3 |
| Third Round | Angelique Kerber | Win | 6-4, 4-6, 6-1 |
| Fourth Round | Anett Kontaveit | Loss | 1-6, 0-2 Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Irina-Camelia Begu | Win | 6-7 (3-7), 6-3, 6-3 |
| Second Round | Dominika Cibulkova | Win | 6-2, 6-2 |
| Third Round | Stefanie Voegele | Win | 6-1, 6-2 |
| Fourth Round | Qiang Wang | Win | 7-5, 6-2 |
| Quarterfinals | Garbine Muguruza | Win | 6-0, 6-1 |
| Semifinals | Elina Svitolina | Win | 6-3, 2-6, 6-4 |
| Final | Angelique Kerber | Win | 6-4, 3-6, 6-4 |
| Abierto Mexicano TELCEL presentado por HSBC | ||
| Surface: Hard | Date: Feb. 25 - Mar. 3 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jil Teichmann | Win | 6-1, 6-3 |
| Second Round | Mihaela Buzarnescu | Win | 6-2, 7-5 |
| Quarterfinals | Saisai Zheng | Win | 7-6 (7-3), 6-1 |
| Semifinals | Sofia Kenin | Loss | 4-6, 6-3, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Whitney Osuigwe | Win | 7-6 (7-1), 6-7 (0-7), 6-3 |
| Second Round | Anastasija Sevastova | Loss | 3-6, 6-3, 2-6 |
| ASB Classic | ||
| Surface: Hard | Date: Dec. 31 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Timea Babos | Win | 6-4, 7-6 (7-6) |
| Second Round | Caroline Wozniacki | Win | 6-4, 6-4 |
| Quarterfinals | Venus Williams | Win | 6-7 (1-7), 6-1, 6-3 |
| Semifinals | Su-Wei Hsieh | Win | 6-3, 6-3 |
| Final | Julia Goerges | Loss | 6-2, 5-7, 1-6 |
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